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Detection of alphavirus replication depends on cellular pattern recognition receptors

Read the full article on ScienceDirect   RIG-I and MDA5 responsible for replication detection   Alphaviruses are the group of widely distributed human and animal pathogens. In cultured cells, their replication results in a very rapid inhibition of cellular transcription, which prevents type I IFN induction and activation of cellular antiviral mechanisms. These effects promote…

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Discovery of a virus

Read the full article on ScienceDirect Isolation and characterization of a virus infecting the freshwater algae Chrysochromulina parva The major result of our study was the discovery of a new virus, CpV-BQ1, which infects the freshwater algae Chrysochromulina parva. Until now, the only known freshwater algal viruses were viruses that infect Chlorella-like algae that were…

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Assembly Instructions: T7 Ejectosome

Read the full article on ScienceDirect The T7 ejection nanomachine components gp15–gp16 form a spiral ring complex that binds DNA and a lipid membrane Text by Sebastian Leptihn and Andreas Kuhn Most people may have heard of T7 phage only from its promoter found in many plasmids used for high level expression in strains carrying…

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Patient-adapted, specific activation of HIV-1 by customized TAL effectors (TALEs)

Read the full article on ScienceDirect A proof of principle study Novel procedures to cure infections with human immunodeficiency virus (HIV-1) aim at eradicating ‘latently infected cells’. These cells carry the HIV genetic information (‘provirus’) integrated in their genomes but show a low or no viral gene expression. This characteristic makes these cells invisible for…

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Study shows that poliovirus and reovirus use fundamentally different transport mechanisms

Read the full article on ScienceDirect A collaborative effort to compare dissemination of three viruses This study was based upon previous work from our lab showing that host barriers restrict poliovirus dissemination in mice. Specifically, poliovirus dissemination to the central nervous system was limited by inefficient transport in neurons and by type I interferon responses…

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Learn how Poliovirus makes efficient use of its limited coding capacity by using multifunctional precursor proteins

Read the full article on ScienceDirect Viral precursor protein P3 and its processed products perform discrete and essential functions in the PV RNA replication complex Poliovirus (PV) is one of the best characterized RNA viruses known, yet a host of questions remain regarding the molecular mechanisms that drive viral replication. In the search for new…

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How can the newly discovered Lloviu virus affect our health?

Read the full article on ScienceDirect Lloviu virus disrupts human innate immune signaling pathways, just like Ebola The filoviruses Ebola virus (EBOV) and Marburg virus (MARV) are zoonotic pathogens that are highly lethal in humans. Until recently, filoviruses were only known to circulate in Africa or the Philippines. Therefore, it was surprising when the sequence…

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To fit in – the conforming behavior of viruses

Read the full article on ScienceDirect Equilibrium in virus populations Virus populations are a common feature of perennial crop infections, but we know very little about how they come to be or how they might change over time. This is important because the structure of a population can determine the type and severity of disease…