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A novel immuno-modulatory role of Nsp2TF of porcine reproductive and respiratory syndrome virus in down-regulation of SLA-I expression

Read the full article on ScienceDirect. The non-structural protein Nsp2TF of porcine reproductive and respiratory syndrome virus down-regulates the expression of Swine Leukocyte Antigen class I Text by Qian M. Cao, Sakthivel Subramaniam, and X.J. Meng Porcine reproductive and respiratory syndrome virus (PRRSV), an arterivirus, circulates in pig farms worldwide causing immense economic losses to…






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Unexpected picornavirus diversity in a single diarrhoeic chicken

Read the full article on ScienceDirect. Complete genome analysis of avian picornaviruses representing up to six genera Text by Ákos Boros In this project our aim was to gain detailed insight into the enteric picornavirus diversity of a single diarrheic chicken introduced recently to a novel location. During the course of our investigation the complete…






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Identification of Structural and Morphogenesis Genes of Pseudoalteromonas phage RIO-1 and Placement within the Evolutionary History of Podoviridae

Read the full article on ScienceDirect. HMM–HMM comparisons find homologous virion proteins across diverse phages Text by Stephen C. Hardies and Byung Cheol Cho   Pseudoalteromonas phage φRIO1 is a marine bacteriophage isolated as part of a project to improve the understanding of the diversity of phages in the marine ecosystem. Initial characterization indicated that…






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Dengue virus’ evaluation with flow virometry

Read the full article on ScienceDirect. Flow virometry used to address the maturation stage of individual virions Text by Sonia Zicari   Dengue virus (DENV) is a small positive single-stranded RNA enveloped Flavivirus that is formed as a non-infectious particle, which undergoes maturation by cleavage of a protein (prM) on its surface. Different prMs are…






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Herpes Simplex Virus sequencing shows stability in the genomes and variability in the technology

Read the full article on ScienceDirect This research article is dedicated to the late Priscilla Shaffer Text by Robin Colgrove   Though well-known to those slogging deep in the genome-sequencing trenches, less-appreciated aspects of NextGen sequencing merit wider exposure among general audiences. Technological advances have made “easy” sequences, well, easy -and rendered “difficult” sequences doable-…






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Mouse papillomavirus MmuPV1 infects oral mucosa and preferentially targets the base of the tongue

Read the article on ScienceDirect Human oral cancers associated with papillomavirus also target the back of the tongue Text by Nancy M. Cladel  Papillomaviruses are ubiquitous and are typically either cutaneotropic or mucosotropic. Most of the infections resolve over time but some do not. When infections persist, significant pathology can occur. Nearly all cases of…






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Detection of alphavirus replication depends on cellular pattern recognition receptors

Read the full article on ScienceDirect   RIG-I and MDA5 responsible for replication detection   Alphaviruses are the group of widely distributed human and animal pathogens. In cultured cells, their replication results in a very rapid inhibition of cellular transcription, which prevents type I IFN induction and activation of cellular antiviral mechanisms. These effects promote…






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Discovery of a virus

Read the full article on ScienceDirect Isolation and characterization of a virus infecting the freshwater algae Chrysochromulina parva The major result of our study was the discovery of a new virus, CpV-BQ1, which infects the freshwater algae Chrysochromulina parva. Until now, the only known freshwater algal viruses were viruses that infect Chlorella-like algae that were…