Genotype displacement events in the lower Columbia River basin and Washington state coast. The Columbia River basin located in Washington (WA), Idaho (ID), and Oregon (OR). Arrows represent dominant genotypes present in each region. Dates of dominance are shown below arrows.

Superinfection fitness does not drive genotype displacement in fish rhabdovirus

Viral fitness does not correlate with three genotype displacement events involving infectious hematopoietic necrosis virus Read the full article on ScienceDirect. Genetic epidemiological studies of the fish rhabdovirus infectious hematopoietic necrosis virus (IHNV) throughout the U.S. Pacific Northwest previously identified three major virus genotype displacement events which occurred in trout over the last 35 years.…

In RSV infected cells and in vitro, the trc promoter sequence (left) can be modified by back-priming. The RNA folds into a secondary structure, with nucleotides 1 and 2 base-pairing with nucleotides 14 and 13, and one to three nucleotides (red) are added to the RNA 3´ end by the viral polymerase (orange oval). Back-priming can also occur on the le promoter sequence in vitro, but does not occur in infected cells.

Understanding respiratory syncytial virus genome synthesis

Factors affecting de novo RNA synthesis and back-priming by the respiratory syncytial virus polymerase Read the full article on ScienceDirect. Respiratory syncytial virus (RSV) is a paramyxovirus, one of the non-segmented negative strand RNA viruses. The long-term goal of our research is to understand how RSV mRNA, antigenome and genome synthesis are regulated. We previously…

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How geminiviruses suppress host antiviral defense

Geminivirus AL2 protein induces expression of, and interacts with, a calmodulin-like gene, an endogenous regulator of gene silencing Read the full article on ScienceDirect. Geminiviruses are plant viruses that cause serious destruction in almost every staple food crop worldwide. Damage caused by geminivirus infections can result in complete crop loss, severely impacting the economic livelihoods…

(A) Photograph of a fire ant (Solenopsis invicta) queen surrounded by workers and immature stages (larvae and pupae). (B) Photograph of a midden pile in a SINV-3-infected colony composed of thousands of dead worker and larval ants.  Note the immature stages (arrows).  Fire ant colonies remove dead or dying colony members from the nest area, which accumulate with time.  (C) Electron micrograph of brood collected from SINV-3-infected midden piles.

Virus changes fire ant behaviour to cause mortality

Solenopsis invicta virus 3: Pathogenesis and stage specificity in red imported fire ants Read the full article on ScienceDirect. Solenopsis invicta virus 3 (SINV-3) is an unclassified plus-strand RNA virus with features suggesting a distant relationship to members of the family Caliciviridae. The virus is specific for the red imported fire ant, Solenopsis invicta Buren.…

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Cell culture systems for hepatitis research

Production and Characterization of High-Titer Serum-Free Cell Culture Grown Hepatitis C Virus Particles of Genotype 1-6 Read the full article for free on ScienceDirect. There is a need for a vaccine against hepatitis C virus (HCV), a major human pathogen. HCV infects >150 million people worldwide, and 3‐4 million new infections occur each year. Recent…