Read the full article on ScienceDirect Most viruses have mechanisms for evading or inhibiting the host’s innate immune response. We have found that the human polyomaviruses, BKV and JCV activate the interferon response and induce an antiviral state when expressed in primary mouse cells. Both the activation of the interferon pathway and the induction of…
Evolution of plant virus movement proteins from the 30K superfamily and of their homologs integrated in plant genomes Read the full article on ScienceDirect This project started as a bioinformatic study of the enigmatic 30K superfamily of plant virus movement proteins (MP). This protein superfamily is widespread in viruses with different kinds of genomes, but, despite…
RNA viruses appear to use oxidative stress generated during infection as a mechanism to control capping their RNA genomes Oxidative stress influences positive strand RNA virus genome synthesis and capping Read the full article on ScienceDirect RNA viruses are known to induce oxidative stress in cells that they infect. While this has long been thought to…
Some double-stranded RNA viruses from fungi utilize a small, pseudoknot-containing RNA cassette to promote stop/restart translation of their RNA polymerase Read the full article on ScienceDirect In 1996, when those of us in the Ghabrial lab reported the sequence of prototype Helminthosporium victoriae virus 190S (HvV190S), of what is now genus Victorivirus in family Totiviridae, we…
Fine structure of the vaccinia virion determined by controlled degradation and immunolocalization Read the full article on ScienceDirect One of the great challenges in the study of the biology of poxviruses is to understand the morphogenesis steps that culminate with the production of the infectious virus particle. To accomplish this task one needs to understand the structure…
Evolutionary genetics and vector adaptation of recombinant viruses of the western equine encephalitis antigenic complex provides new insights into alphavirus diversity and host switching Read the full article on ScienceDirect Alphaviruses are a group of arthropod-borne positive-sense RNA viruses that contain many important human and veterinary pathogens. A notable example is Chikungunya virus (CHIKV), which although…
Roseoloviruses: Ubiquitous in humans and macaques Read the full article on ScienceDirect Human herpesviruses HHV-6A, 6B and 7 are classified as Roseoloviruses within the Betaherpesvirinae subfamily and are highly prevalent in the human population. Following primary infections roseoloviruses establish life-long latency with occasional reactivation. Viral reactivation in immuno-compromised patients can cause severe pathological conditions. Macaques…
Understanding the enormous diversity of bacteriophages: The tailed phages that infect the bacterial family Enterobacteriaceae Read the full article on ScienceDirect. We have long-term interests in the diversity of E. coli/Salmonella phages (Casjens) and Erwinia phages (Grose) and wanted to know how the phages we have studied fit into the bigger picture of phage diversity.…
SMCX and components of the TIP60 complex contribute to E2 regulation of the HPV E6/E7 promoter Read the full article on ScienceDirect. The high-risk human papillomaviruses (HPVs) cause cervical cancer, other anogenital cancers and approximately 20% of head and neck cancers. These cancers are driven by two viral oncoproteins, E6 and E7, that target tumor…
Complementation for an essential ancillary non-structural protein function across parvovirus genera Read the full article on ScienceDirect. Parvoviruses have a small (5kb) single-stranded DNA genome that is almost entirely devoted to the expression of two essential genes; one encoding a rolling-hairpin replication initiator protein with HuH nickase and SF3 AAA+ helicase functions, and a second…
Editors: Richard C. Condit and Matthias G. Fischer Read the Giant Viruses Special Issue on Science Direct for free. The October issue of Virology is a Special Issue on Giant Viruses. Here is an excerpt of the editorial, by Editor Matthias G. Fischer. You can read the editorial in full, for free, on ScienceDirect. Viruses…
Increased virulence of rabbit haemorrhagic disease virus associated with genetic resistance in wild Australian rabbits (Oryctolagus cuniculus) – free access Read the full article on ScienceDirect. The European rabbit (Oryctolagus cuniculus) is an invasive species in into Australia that damages agriculture and wreaks havoc on the environment. To control rabbits, Australia has introduced two different…
Viral fitness does not correlate with three genotype displacement events involving infectious hematopoietic necrosis virus Read the full article on ScienceDirect. Genetic epidemiological studies of the fish rhabdovirus infectious hematopoietic necrosis virus (IHNV) throughout the U.S. Pacific Northwest previously identified three major virus genotype displacement events which occurred in trout over the last 35 years.…
Metagenomic shotgun sequencing of a Bunyavirus in wild-caught Aedes aegypti from Thailand informs the evolutionary and genomic history of the Phleboviruses (Open Access) Read the full article on ScienceDirect. This work began in 2007 fueled by the ambitions of two students, Panpim Thongsripong and Amy Green, who hungered for a better understanding of the evolutionary…
Each of the eight simian hemorrhagic fever virus minor structural proteins is functionally important Read the full article on ScienceDirect. Simian hemorrhagic fever virus (SHFV) is a plus-strand RNA virus in the family Arteriviridae. The SHFV genome is unique in encoding two sets of four minor structural protein open reading frames (ORFs) instead of one.…