Proteome analysis of the HIV-1 Gag interactome Read the full article on ScienceDirect. Isn’t it fascinating how a virus can hijack a number of cellular pathways for its replication – with a limited number of viral proteins? Although HIV is relatively well-studied, many aspects of its replication cycle remain poorly understood. A more thorough characterization…
Geminivirus AL2 protein induces expression of, and interacts with, a calmodulin-like gene, an endogenous regulator of gene silencing Read the full article on ScienceDirect. Geminiviruses are plant viruses that cause serious destruction in almost every staple food crop worldwide. Damage caused by geminivirus infections can result in complete crop loss, severely impacting the economic livelihoods…
Solenopsis invicta virus 3: Pathogenesis and stage specificity in red imported fire ants Read the full article on ScienceDirect. Solenopsis invicta virus 3 (SINV-3) is an unclassified plus-strand RNA virus with features suggesting a distant relationship to members of the family Caliciviridae. The virus is specific for the red imported fire ant, Solenopsis invicta Buren.…
Modulation of innate immune signaling by the secreted form of the West Nile virus NS1 glycoprotein Read the full article on ScienceDirect. West Nile virus (WNV) is a member of the family Flaviviridae and is known to employ several different strategies to escape immune detection. The innate immune response is the first line of defense…
Production and Characterization of High-Titer Serum-Free Cell Culture Grown Hepatitis C Virus Particles of Genotype 1-6 Read the full article for free on ScienceDirect. There is a need for a vaccine against hepatitis C virus (HCV), a major human pathogen. HCV infects >150 million people worldwide, and 3‐4 million new infections occur each year. Recent…
Enhanced human receptor binding by H5 haemagglutinins Read the full article on ScienceDirect. Virologists and public health officials share an interest in the mechanism of influenza virus cross-species transmission because of the potential of newly introduced viruses to cause pandemics. Analyses of naturally and experimentally transmitted viruses indicate roles for several gene products in the…
In this continuing series of blog posts, the Editor-in-Chief of Virology, Michael Emerman, recommends books chosen for their descriptions of the roles of viruses and viral disease in the broader contexts of human health, society and history. This is part 4, with books about Smallpox and about Prions. Pox Americana: The Great Smallpox Epidemic of…
Constraints from protein structure and intra-molecular coevolution influence the fitness of HIV-1 recombinants Read the full article on ScienceDirect. HIV-1 infections remain a major cause of human disease. The main reason for our inability to provide a cure is the virus’s very high rate of evolution. This leads to several negative consequences, including the virus’s…
Evaluation of the antigenic relatedness and cross-protective immunity of the neuraminidase between human influenza A (H1N1) virus and highly pathogenic avian influenza A (H5N1) virus Read the full article on ScienceDirect. With continued human cases of highly pathogenic H5N1 avian influenza virus infection, there is a concern that this virus could cause a pandemic. A…
Static and dynamic protein phosphorylation in the Vaccinia virion Read the full article on ScienceDirect. Alongside the histone modification code and the CTD phosphorylation code for RNA polymerase II, is there a virion assembly phosphocode for complex virions such as those of the poxvirus family? Although the existence of phosphoproteins in the vaccinia virion has…
In this continuing series of blog posts, the Editor-in-Chief of Virology, Michael Emerman, recommends books chosen for their descriptions of the roles of viruses and viral disease in the broader contexts of human health, society and history. Here’s part 3 with two books about HIV/AIDS. And the Band Played On: Politics, People, and the AIDS…
The p33 auxiliary replicase protein of Cucumber necrosis virus targets peroxisomes and infection induces de novo peroxisome formation from the endoplasmic reticulum Read the full article on ScienceDirect. Viruses replicate on intracellular membranes of the host and most often induce proliferation as well as remodelling of host membranes. Cucumber necrosis virus is a plus-strand RNA…
Penetration of pollen tubes with accumulated Raspberry bushy dwarf virus into stigmas is involved in initial infection of maternal tissue and horizontal transmission Read the full article on ScienceDirect – free access Pollination is an essential step in the reproduction of flowering plants and is also crucial in agriculture in regard to fruit development, seed…
Genome rearrangement of a mycovirus Rosellinia necatrix megabirnavirus 1 affecting its ability to attenuate virulence of the host fungus Read the full article on ScienceDirect. Mycoviruses are viruses that infect fungi. Most mycoviruses are asymptomatic, but some induce phenotypical changes in their host fungi. Previous examination of field isolates of the destructive root rot pathogen…
Orsay virus utilizes ribosomal frameshifting to express a novel protein that is incorporated into virions Read the full article on ScienceDirect. Orsay virus is the first identified virus capable of naturally infecting Caenorhabditis elegans. Our recent discovery of Orsay virus along with two other nematode infecting viruses, Santueil and Le Blanc, enables for the first…
