Static and dynamic protein phosphorylation in the Vaccinia virion Read the full article on ScienceDirect. Alongside the histone modification code and the CTD phosphorylation code for RNA polymerase II, is there a virion assembly phosphocode for complex virions such as those of the poxvirus family? Although the existence of phosphoproteins in the vaccinia virion has…
In this continuing series of blog posts, the Editor-in-Chief of Virology, Michael Emerman, recommends books chosen for their descriptions of the roles of viruses and viral disease in the broader contexts of human health, society and history. Here’s part 3 with two books about HIV/AIDS. And the Band Played On: Politics, People, and the AIDS…
The p33 auxiliary replicase protein of Cucumber necrosis virus targets peroxisomes and infection induces de novo peroxisome formation from the endoplasmic reticulum Read the full article on ScienceDirect. Viruses replicate on intracellular membranes of the host and most often induce proliferation as well as remodelling of host membranes. Cucumber necrosis virus is a plus-strand RNA…
Penetration of pollen tubes with accumulated Raspberry bushy dwarf virus into stigmas is involved in initial infection of maternal tissue and horizontal transmission Read the full article on ScienceDirect – free access Pollination is an essential step in the reproduction of flowering plants and is also crucial in agriculture in regard to fruit development, seed…
Genome rearrangement of a mycovirus Rosellinia necatrix megabirnavirus 1 affecting its ability to attenuate virulence of the host fungus Read the full article on ScienceDirect. Mycoviruses are viruses that infect fungi. Most mycoviruses are asymptomatic, but some induce phenotypical changes in their host fungi. Previous examination of field isolates of the destructive root rot pathogen…
Orsay virus utilizes ribosomal frameshifting to express a novel protein that is incorporated into virions Read the full article on ScienceDirect. Orsay virus is the first identified virus capable of naturally infecting Caenorhabditis elegans. Our recent discovery of Orsay virus along with two other nematode infecting viruses, Santueil and Le Blanc, enables for the first…
In vitro selection of the 3′-untranslated regions of the human liver mRNA that bind to the HCV nonstructural protein 5B Read the full article on ScienceDirect. After evading the innate immune system, the hepatitis C virus (HCV) efficiently establishes a persistent infection in which immune-mediated liver injury develops chronic hepatitis. The molecular mechanisms advantageous to…
The emergence and evolution of the novel epidemic norovirus GII.4 variant Sydney 2012 Read the full article on ScienceDirect. Noroviruses are the most common cause of acute gastroenteritis, globally, and have become increasingly notorious in recent years following a number of devastating pandemics that caused the widespread shutdown of nursing homes, hospitals and child care…
In this continuing series of blog posts, the Editor-in-Chief of Virology, Michael Emerman, recommends books chosen for their descriptions of the roles of viruses and viral disease in the broader contexts of human health, society and history. Here’s part 2, with a book about polio and another on influenza. Polio: An American Story – David…
Estimating the fraction of progeny virions that must incorporate APOBEC3G for suppression of productive HIV-1 infection Read the full article on ScienceDirect. The interaction between the human protein APOBEC3G (A3G) and the HIV protein Vif is a remarkable example of the evolutionary arms race between viruses and their hosts. A3G expressed in HIV infected cells…
Turnip crinkle virus coat protein inhibits the basal immune response to virus invasion in Arabidopsis by binding to the NAC transcription factor TIP Read the full article on ScienceDirect. The innate immune system used in any organism against a pathogen is a complicated dance of gene expression and protein interaction. Therefore a major challenge in…
Differential cleavage of IRES trans-acting factors (ITAFs) in cells infected by human rhinovirus Read the full article on ScienceDirect. Human rhinovirus (HRV) is a major causative agent of the common cold and has important health implications, especially for individuals suffering from asthma or chronic obstructive pulmonary disease. Understanding HRV RNA replication and how it interacts…
In this new series of blog posts on Virology Highlights, the Editor-in-Chief of Virology, Michael Emerman, recommends reading material for virologists and others interested in viruses and their impacts. These are not textbooks or reference books, but rather books chosen for their descriptions of the roles of viruses and viral disease in the broader contexts…
Pandemic H1N1 influenza A directly induces a robust and acute inflammatory gene signature in primary human bronchial epithelial cells downstream of membrane fusion Read the full article on ScienceDirect. When the pandemic H1N1 flu virus emerged in 2009 (H1N1pdm) it was clear that infection in humans led to significant lung damage where disease was strikingly…
Methylation of translation elongation factor 1A by the METTL10-like See1 methyltransferase facilitates tombusvirus replication in yeast and plants Read the full article on ScienceDirect. Viruses are intracellular parasites that take advantage of the host cell’s resources, including subcellular membranes and host proteins for their replication. The multiplication of the viral RNA for the plant-infecting tombusviruses…
