Virology welcomes three new editors

Virology is very pleased to announce the appointment of three new Editors. We are excited by the expertise that these new additions contribute to our distinguished group of Editors handling manuscripts submitted to the journal. We honor the contributions of Editors rotating off: Sara Cherry, Paul Lambert, Michael Oldstone, and Jerry Zack.

Introducing the new editors

Greg Ebel, Arthropod-borne and Infectious Diseases Laboratory, Department of Microbiology Immunology and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University

Greg Ebel, Colorado State University
Areas of expertise: Arboviruses

Greg grew up in Minnesota and attended the University of Minnesota in Minneapolis as an undergraduate. He went to graduate school at the Harvard School of Public Health, where he worked on Powassan virus, a tick-transmitted flavivirus. After graduating, Greg moved to the Wadsworth Center, part of the New York State Health Department, to be part of the response to West Nile virus, which had recently been introduced into NYC. He has worked on arboviruses ever since, first as a faculty member at the University of New Mexico Medical School, and currently at Colorado State University.

Microbiology & Immunology

Martha A. Alexander-Miller, Wake Forest School of Medicine
Areas of expertise: human and nonhuman primate viral immunology and vaccines, immunity to respiratory infection

Martha was raised on a farm in Indiana. She attended Butler University in Indianapolis, where she received her undergraduate degree in Zoology. Martha entered Washington University in St. Louis to pursue a PhD in Immunology.  There she first began studying the mechanisms that controlled CD8+ T cell activation. Martha pursued postdoctoral training at the National Institutes of Health where she continued to unravel the diversity in the T cell repertoire with regard to functional avidity. She accepted a position at Wake Forest School of Medicine where her program expanded to include studies of immune regulation as a result of respiratory virus infection and vaccine development, with a special emphasis on neonate immunity. For these studies a nonhuman primate neonate model was developed that has proved invaluable for assessing potential vaccine candidates.

McBride 2018Alison McBride, National Institute of Health
Areas of expertise:   Papillomaviruses; Polyomaviruses; Adenoviruses

Alison is from Scotland and received a B.Sc. from the University of Glasgow. As an undergraduate, she was greatly inspired by the virologists in the Institute of Virology and this led her to the Imperial Cancer Research Fund in London to study Epstein-Barr virus for her Ph.D. She was privileged to be there when many exciting discoveries were being made in DNA Tumor Virology. Next stop was a “two-year post-doc” at the National Institutes of Health (NIH) in the US, to study papillomaviruses.  Two years turned into thirty and her laboratory at the NIH still focuses on papillomaviruses.

Q. What subjects will you be covering in Virology?

Greg: “I will be covering arboviruses for Virology. Arboviruses are those viruses that are transmitted by the bite of an arthropod, typically mosquitoes and ticks. The field of arbovirology tends to be very interdisciplinary, so I anticipate covering manuscripts that deal with arbovirus transmission, evolution, pathogenesis, host-virus interactions and other topics relating to this interesting field.”

Martha: “I will be focused on nonhuman primate and human immune studies in the context of infection and vaccination.”

Alison: “I will be covering the non-enveloped, dsDNA viruses: papillomaviruses, polyomaviruses and adenoviruses. Topics will likely range from viral evolution, viral-host interaction, pathogenesis, oncogenesis, therapeutics, detection, viral vectors, and more.”

Q. Why are these subjects important?  

Greg: “Arboviruses such as yellow fever virus and dengue virus have been significant health concerns for decades (even centuries). In recent years, however, arboviruses have emerged in explosive outbreaks as major global pathogens. Understanding their biology is central to devising new countermeasures and managing emergence in the future. We are in a “golden age” of arbovirology.”

Martha: “As our understanding of the immune system continues to grow, we are increasingly aware of the highly orchestrated interaction of multiple cell types and the molecules expressed by these cells that are required to develop an effective immune response following virus infection. There is a growing appreciation of the advantages offered by nonhuman primate models.  Utilization of nonhuman primate models, which allow in vivo mechanistic testing, along with in vitro studies of human cells allow for critical insights that facilitate our understanding of host pathogen interaction and promote the optimal design of vaccines and therapeutics.”

Alison: “These viruses are significant human pathogens, but also provide great insight into the biology of their hosts. For example, oncogenic human papillomaviruses are associated with ~5% human cancers; the polyomavirus family has expanded rapidly as new members have been discovered in recent years; and adenovirus-based vectors are being intensively developed as cancer and gene therapy vectors.”

Q.What do you see in the future of the field?

Greg: “It is likely that arboviruses will continue to emerge on a global scale. This is due to several factors including increases in travel and trade, the rise of tropical megacities and associated populations that are vulnerable for a wide array of reasons. The field will need to meet the challenges posed by these ongoing problems.”

Martha: “In addition to the viral infections that continue to elude development of effective therapies and vaccines, there is a constant threat of new emerging pathogens.  Success in combating these viral pathogens requires a detailed understanding of how they evade/modulate the immune response and the immune effectors that best promote clearance and protection.  I believe studies in models that most effectively mimic the human host will provide novel insights that can significantly move the field forward and thus studies in this area will continue to grow over the foreseeable future. ”

Alison: “The small DNA tumor viruses will continue to amaze us with their ability to manipulate key cellular pathways, with broad implications for biology. Understanding, and harnessing, these strategies will assist in the development of small-molecule, oncolytic and immune therapeutics.”

The new editors have selected 6 articles of interest in their subject areas:

Mouse papillomavirus MmuPV1 infects oral mucosa and preferentially targets the base of the tongue
Virology, Volume 488, 15 January 2016, Pages 73-80

The Rb binding domain of HPV31 E7 is required to maintain high levels of DNA repair factors in infected cells
Virology, Volume 500, January 2017, Pages 22-34

 The Zika virus envelope protein glycan loop regulates virion antigenicity
Virology, Volume 515, February 2018, Pages 191-202

West African Anopheles gambiae mosquitoes harbor a taxonomically diverse virome including new insect-specific flaviviruses, mononegaviruses, and totiviruses
Virology, Volume 498, November 2016, Pages 288-299

Development of live-attenuated arenavirus vaccines based on codon deoptimization of the viral glycoprotein
Virology, Volume 501, 15 January 2017, Pages 35-46

3B11-N, a monoclonal antibody against MERS-CoV, reduces lung pathology in rhesus monkeys following intratracheal inoculation of MERS-CoV Jordan-n3/2012
Virology, Volume 490, March 2016, Pages 49-58

Go to the Editorial Board page for the full Editorial Board member list